Fluconazole is one of the leaders among antifungal drugs with good tolerability and high activity. He is causing not only ordinary thrush, but also more serious forms of mycoses.
General information about fluconazole
Fluconazole is capsules with the content of the same name of the active substance in the form of a white or yellowish yellowish powder. This is a synthetic preparation that is produced in several forms:
- capsules for intakes (0.05 g, 0.1g, 0.15g and 0.25 g);
- suspension for intake (60 ml);
- solution for infusions (50 ml).
The drug is characterized by good pharmacological properties, which cause its effectiveness. It is well absorbed, independent of meals, creates a high concentration of active substance in the blood (up to 90%) and is long derived from the body. Thanks to the last two qualities, fluconazole does not require frequent reception and is mainly prescribed 1-2 times a day.
Analogs of the drug in composition and action - Diflycan, microsist, diphlasone, flukostat.
Application and dose
The spectrum of antifungal action of fluconazole is quite wide - it is prescribed for the treatment of local lesions of the skin and mucosa (candidiasis, mycoses, a decent-shaped deprived), with cryptococcal infections, as well as generalized (common, systemic) fungal lesions. Therefore, the doses of it can be different:
- under candidiasis of mucous membranes, skinmic mothos - 0.05 g per day for 1-4 weeks, vaginal candidiasis - 0.15 g of one-time;
- with onychomicosis - 0.15 g per week (until a complete shift of the affected nail plate);
- with system candidides - from 0.1 to 0.2 g per day with adults and 3-6 mg per 1 kg of mass of children;
- with cryptococcal meningitis - from 0.2 to 0.4 g per day to 2 months;
- with a deceased lisha - 3 g per week (1-3 weeks).
If the drug is prescribed in the form of intravenous infusion, the adult is introduced with a speed of 5-10 ml / min. Children This form of fluconazole is applied at the rate of 1-2 mg per 1 kg of the child's mass.
Prevention of fungal diseases
It is noteworthy that fluconazole is not always used as a drug to combat the already emerged disease. It is often prescribed to prevent the development of fungal infections in the case of immunity weakened by severe diseases (tumors, AIDS, during transplantation operations). At the same time, the main therapeutic doses of the drug in any of the listed cases are prescribed exclusively by the doctor, based on the diagnosis and severity of the state.
Contraindications for the use of fluconazole
Contraindications to the use of fluconazole fell:
- individual intolerance to the drug,
- pregnancy,
- lactation.
- children's age (up to 4 years).
With great care, you should treat the medicine in the event that there are problems with the kidneys and the liver in the form of failure, heart, as well as while taking preparations with hepatotoxic or arrhythmogenic effects.
Side Effects and Overdose
Our body can respond to the introduction of fluconazole in different ways, including the "protest" in the form of side effects. The most common reactions for the rejection of the drug are as follows:
- on the part of the digestive system - nausea, lack of appetite, pain, bloating, diarrhea, flavoring anomalies;
- from the nervous system - headaches, dizziness;
- from the immune system - rash.
In severe cases of intolerance to fluconazole, the drug can lead to convulsions, disorders of the kidney, arrhythmic or anaphylactic states.
The abnormalization of the body drug leads to hallucinations and paranoid behavioral reactions.
Additional information about fluconazole
Since the freakonazole is most often included in the treatment regimen along with other drugs, it is necessary to take into account their compatibility. And more precisely, the fluconazole stimulates the effect of sulfylmourium-based preparations, phenytoin, hydrochlorosticiazide, as well as anticoagulants.
To store the drug you need to highlight shaded, cool, inaccessible place for children. The shelf life depends on the manufacturer and can be from 2 to 5 years.
Fluconazole is an effective drug that, with a properly selected dose and the correct diagnosis, is able to solve the "fungal" problem of any scale. However, both listed conditions must proceed exclusively from a specialist doctor, since self-treatment can only aggravate the state.
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