Omeprazole is a drug that reduces gastric juice acidity. It is used in the treatment of hyperacid gastritis, peptic ulcer of the stomach and a twelfth intestine, reflux disease.
Mechanism of action and properties of omeprazole
Omeprazole refers to proton pump inhibitors. Activant in hydrochloric acid, the drug slows down the work of proton pumps of stomach parietal cells. The secretion of hydrochloric acid and the acidity of the gastric juice decreases. The maximum concentration of the drug in the body is reached after 1-3 hours from the date of reception. Metabolized in the liver, followed by the elimination of kidneys from the body. In some cases, it can cause diarrhea, vomiting, pain in the stomach and dry mouth.
Method of application and dosage omeprazole
The drug is produced in capsules. In one capsule contains 20 mg of the active substance. Take it inside for 30 minutes. Before the food, drinking a large amount of liquid.
- With gastritis and reflux disease, 20 mg per day is recommended.
- For ulcerative diseases of the stomach and twelve intestine, increase the dose of up to 40 mg per day per reception.
- In case of erosive gastritis with a high degree of activity, the dose increases to 80 mg per day for 2-3 reception.
- For the prevention of recurrence of peptic ulcer and heartburn, take 20 mg of omeprazole in a day.
Interaction and special instructions
Omeprazole reduces suction activity in the stomachranezole, iron and ampicillin. Inhibits the activity of dibazole and anticoagulants. Do not take the drug when suspected of gastric cancer and during breastfeeding period. With liver failure, the dose should not exceed 20 mg. The drug is contraindicated to the use of children under 12 years and patients with renal failure.
Proton pump inhibitors are widely distributed in gastroenterology. Omeprazole is the main representative. It is used in most cases to reduce the acidity of gastric juice.
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